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buy glimepiride The title character, played by Oscar Isaac, is a man of deep contrasts. He's a jerk who uses other people, and the Coens throw misfortunes his way. They're positively fiendish. We watch his money run out and options shrink, and though we wait for something better ??? as in a standard rags-to-riches showbiz tale ??? it seems as if each anvil dropping on his head is heavier than the last.